Reinnervation following catheter-based radio-frequency renal denervation

LC Booth; EE Nishi; ST Yao; R Ramchandra; GW Lambert; MP Schlaich; CN May

Journal article

Reinnervation following catheter-based radio-frequency renal denervation

LC Booth, EE Nishi, ST Yao, R Ramchandra, GW Lambert, MP Schlaich, CN May

Experimental Physiology | Published : 2015

DOI: 10.1113/expphysiol.2014.079871

Abstract

New Findings: What is the topic of this review? Does catheter-based renal denervation effectively denervate the afferent and efferent renal nerves and does reinnervation occur? What advances does it highlight? Following catheter-based renal denervation, the afferent and efferent responses to electrical stimulation were abolished, renal sympathetic nerve activity was absent, and levels of renal noradrenaline and immunohistochemistry for tyrosine hydroxylase and calcitonin gene-related peptide were significantly reduced. By 11 months after renal denervation, both the functional responses and anatomical markers of afferent and efferent renal nerves had returned to normal, indicating reinnervati..

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University of Melbourne Researchers

Lindsea Booth Author

Song Yao Author

Clive May Author

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Grants

Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia (NHMRC; 1012100) and the Victorian Government's Operational Infrastructure Support Program. L.C.B. was the recipient of a NHMRC Early Career Fellowship (1054619), E.E.N. was supported by Research Internships Abroad Fellowship of Sao Paulo Research Foundation, and C.N.M., M.P.S. and G.W.L. were supported by NHMRC Research Fellowships.